醋酸泼尼松片辅助治疗带状疱疹后神经痛的效果及对睡眠的影响(1)
【摘要】 目的：研究醋酸潑尼松片辅助治疗带状疱疹后神经痛的效果及对睡眠的影响。方法：选择2017年6月-2019年6月笔者所在医院接收的带状疱疹后神经痛患者100例，使用随机数字表法将其分为对照组和研究组，每组50例。对照组使用普瑞巴林治疗，研究组在对照组的基础上使用醋酸泼尼松片辅助治疗。对比两组临床疗效、炎症因子水平、焦虑和睡眠状况。结果：研究组治疗总有效率(96.00%)高于对照组(84.00%)，差异有统计学意义(P<0.05);治疗后研究组IL-10低于对照组，IL-2高于对照组，差异均有统计学意义(P<0.05);治疗后研究组HAMD和PSQL评分均低于对照组，差异均有统计学意义(P<0.05);研究组不良反应总发生率(12.00%)与对照组(16.00%)比较差异无统计学意义(P>0.05)。结论：醋酸泼尼松片结合普瑞巴林治疗带状疱疹后神经痛的效果显著，并且能够改善患者的炎症因子水、焦虑和睡眠状况。
【关键词】 醋酸泼尼松片 普瑞巴林 带状疱疹 神经痛
doi：10.14033/j.cnki.cfmr.2020.22.055 文献标识码 B 文章编号 1674-6805(2020)22-0-03
[Abstract] Objective： To study the effect of Prednisone Acetate Tablets on postherpetic neuralgia and its effect on sleep. Method： A total of 100 patients with postherpetic neuralgia admitted to the our hospital from June 2017 to June 2019 were selected and divided into the control group and the study group by random number table method， with 50 patients in each group. The control group was treated with Pregabalin， and the study group was treated with Prednisone Acetate Tablets on the basis of the control group. The clinical efficacy， inflammatory factor level， anxiety and sleep status of the two groups were compared. Result： The total effective rate of treatment in the study group (96.00%) was higher than that in the control group (84.00%)， the difference was statistically significant (P<0.05). After treatment， IL-10 in the study group was lower than that in the control group， and IL-2 was higher than that in the control group， the differences were statistically significant (P<0.05). After treatment， the HAMD and PSQL scores in the treatment group were lower than those in the control group， the differences were statistically significant (P<0.05). The total incidence of adverse reactions in the study group (12.00%) and the control group (16.00%) had no statistically significant difference (P>0.05). Conclusion： Prednisone Acetate Tablets combined with Pregabalin is effective in the treatment of postherpetic neuralgia， and can improve the inflammatory factors such as water， anxiety and sleep.
[Key words] Prednisone Acetate Tablets Pregabalin Herpes zoster Neuralgia
First-author’s address： Sihui People’s Hospital， Sihui 526200， China
带状疱疹是由水痘-带状疱疹病毒感染所致的，感染后局部常发生炎症反应并伴有剧烈的神经疼痛，影响患者的睡眠，导致焦虑心理的产生[1]。普瑞巴林具有抗癫痫、镇痛、抗抑郁的作用，是目前首选的治疗药物[2]，但是普瑞巴林单独用药的效果不佳，并且不良反应较明显[3]，糖皮质激素能够减轻炎症反应，从而起到缓解神经疼痛的作用[4]，醋酸泼尼松片是一种肾上腺皮质激素类药，普瑞巴林联合醋酸泼尼松片治疗带状疱疹后神经痛或许能够起到更好的效果，因此本文研究醋酸泼尼松片辅助治疗应用于带状疱疹后神经痛的效果及对睡眠的影响，报道如下。, 百拇医药(唐卓润 梁天梅)
【关键词】 醋酸泼尼松片 普瑞巴林 带状疱疹 神经痛
doi：10.14033/j.cnki.cfmr.2020.22.055 文献标识码 B 文章编号 1674-6805(2020)22-0-03
[Abstract] Objective： To study the effect of Prednisone Acetate Tablets on postherpetic neuralgia and its effect on sleep. Method： A total of 100 patients with postherpetic neuralgia admitted to the our hospital from June 2017 to June 2019 were selected and divided into the control group and the study group by random number table method， with 50 patients in each group. The control group was treated with Pregabalin， and the study group was treated with Prednisone Acetate Tablets on the basis of the control group. The clinical efficacy， inflammatory factor level， anxiety and sleep status of the two groups were compared. Result： The total effective rate of treatment in the study group (96.00%) was higher than that in the control group (84.00%)， the difference was statistically significant (P<0.05). After treatment， IL-10 in the study group was lower than that in the control group， and IL-2 was higher than that in the control group， the differences were statistically significant (P<0.05). After treatment， the HAMD and PSQL scores in the treatment group were lower than those in the control group， the differences were statistically significant (P<0.05). The total incidence of adverse reactions in the study group (12.00%) and the control group (16.00%) had no statistically significant difference (P>0.05). Conclusion： Prednisone Acetate Tablets combined with Pregabalin is effective in the treatment of postherpetic neuralgia， and can improve the inflammatory factors such as water， anxiety and sleep.
[Key words] Prednisone Acetate Tablets Pregabalin Herpes zoster Neuralgia
First-author’s address： Sihui People’s Hospital， Sihui 526200， China
带状疱疹是由水痘-带状疱疹病毒感染所致的，感染后局部常发生炎症反应并伴有剧烈的神经疼痛，影响患者的睡眠，导致焦虑心理的产生[1]。普瑞巴林具有抗癫痫、镇痛、抗抑郁的作用，是目前首选的治疗药物[2]，但是普瑞巴林单独用药的效果不佳，并且不良反应较明显[3]，糖皮质激素能够减轻炎症反应，从而起到缓解神经疼痛的作用[4]，醋酸泼尼松片是一种肾上腺皮质激素类药，普瑞巴林联合醋酸泼尼松片治疗带状疱疹后神经痛或许能够起到更好的效果，因此本文研究醋酸泼尼松片辅助治疗应用于带状疱疹后神经痛的效果及对睡眠的影响，报道如下。, 百拇医药(唐卓润 梁天梅)