琥珀酸美托洛尔缓释片治疗慢性充血性心力衰竭的临床效果观察(1)
【摘要】 目的 观察琥珀酸美托洛尔缓释片治疗慢性充血性心力衰竭的临床效果。方法 102例慢性充血性心力衰竭患者， 采用双色球分组法分为对照组和观察组， 各51例。对照组患者采用常规治疗， 观察组患者在对照组基础上加用琥珀酸美托洛尔缓释片进行治疗。对比两组患者治疗前后左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左室射血分数(LVEF)及临床治疗效果。结果 治疗后两组患者LVEDD、LVESD以及LVEF水平均优于治疗前， 且观察组优于对照组， 差异均具有统计学意义 (P<0.05)。观察组患者的临床治疗总有效率为90.20%， 高于对照组的74.51%， 差异具有统计学意义 (P<0.05)。结论 琥珀酸美托洛尔缓释片治疗慢性充血性心力衰竭临床效果显著， 可有效改善患者心功能， 值得在临床中推广应用。
【关键词】 琥珀酸美托洛尔缓释片；慢性充血性心力衰竭；临床效果
DOI：10.14163/j.cnki.11-5547/r.2016.34.048
Clinical effect observation on metoprolol succinate sustdined-release tablets in the treatment of chronic congestive heart failure SUN Chang， ZHANG Chun-min， LUO Wu-kui. Department Two of Internal Medicine， Heyuan City Heping County People’s Hospital， Heyuan 517200， China
【Abstract】 Objective To observe clinical effect of metoprolol succinate sustdined-release tablets in the treatment of chronic congestive heart failure. Methods A total of 102 chronic congestive heart failure patients were divided by double chromosphere into control group and observation group， with 51 cases in each group. The control group received conventional treatment， and observation group also received metoprolol succinate sustdined-release tablets for treatment. Comparison were made on left ventricular end diastolic dimension (LVEDD)， left ventricular end systolic dimension (LVESD)， left ventricular ejection fraction (LVEF) and clinical effect between two groups before and after treatment. Results Both groups had better level of LVEDD， LVESD and LVEF after treatment than before treatment， and observation group had lower level than control group， all differences had statistical significance (P<0.05) . The observation group had clinical total effective rate as 90.20%， which was higher than 74.51% in control group， and difference ahd statistical significance (P<0.05). Conclusion Implement of metoprolol succinate sustdined-release tablets shows clear clinical effect in improve cardiac function of chronic congestive heart failure patients， and this method is worth clinical promotion and application.
【Key words】 Metoprolol succinate sustdined-release tablets； Chronic congestive heart failure； Clinical effect
慢性充血性心力衰竭是許多心血管疾病的终末阶段， 临床主要表现为呼吸困难、体液潴留以及乏力等[1-4]， 临床死亡率较高[2]。近年来， 临床中慢性充血性心力衰竭患者数量不断上涨， 对患者的生命安全有较大威胁。本文将本院收治的102例慢性充血性心力衰竭患者作为研究对象， 观察琥珀酸美托洛尔缓释片治疗慢性充血性心力衰竭的临床效果。现报告如下。
1 资料与方法
1. 1 一般资料 将本院2014年9月～2015年12月收治的102例慢性充血性心力衰竭患者纳入本次研讨范围， 采用双色球分组法分为对照组和观察组， 各51例。所有患者均符合慢性充血性心力衰竭相关诊断标准[3]；且对本次研究知情， 并签署知情同意书。排除琥珀酸美托洛尔缓释片以及其他相关药物禁忌者。对照组中， 男33例， 女18例；年龄63～82岁， 平均年龄(70.5±6.4)岁；心功能按纽约心脏病协会(NYHA)分级[5]， Ⅱ级14例， Ⅲ级27例， Ⅳ级10例。观察组中， 男32例， 女19例；年龄61～82岁， 平均年龄(69.7±6.3)岁；心功能按NYHA分级， Ⅱ级16例， Ⅲ级26例， Ⅳ级9例。两组患者一般资料比较， 差异无统计学意义(P>0.05)， 具有可比性。, http://www.100md.com(孙畅 张春敏 罗武奎)
【关键词】 琥珀酸美托洛尔缓释片；慢性充血性心力衰竭；临床效果
DOI：10.14163/j.cnki.11-5547/r.2016.34.048
Clinical effect observation on metoprolol succinate sustdined-release tablets in the treatment of chronic congestive heart failure SUN Chang， ZHANG Chun-min， LUO Wu-kui. Department Two of Internal Medicine， Heyuan City Heping County People’s Hospital， Heyuan 517200， China
【Abstract】 Objective To observe clinical effect of metoprolol succinate sustdined-release tablets in the treatment of chronic congestive heart failure. Methods A total of 102 chronic congestive heart failure patients were divided by double chromosphere into control group and observation group， with 51 cases in each group. The control group received conventional treatment， and observation group also received metoprolol succinate sustdined-release tablets for treatment. Comparison were made on left ventricular end diastolic dimension (LVEDD)， left ventricular end systolic dimension (LVESD)， left ventricular ejection fraction (LVEF) and clinical effect between two groups before and after treatment. Results Both groups had better level of LVEDD， LVESD and LVEF after treatment than before treatment， and observation group had lower level than control group， all differences had statistical significance (P<0.05) . The observation group had clinical total effective rate as 90.20%， which was higher than 74.51% in control group， and difference ahd statistical significance (P<0.05). Conclusion Implement of metoprolol succinate sustdined-release tablets shows clear clinical effect in improve cardiac function of chronic congestive heart failure patients， and this method is worth clinical promotion and application.
【Key words】 Metoprolol succinate sustdined-release tablets； Chronic congestive heart failure； Clinical effect
慢性充血性心力衰竭是許多心血管疾病的终末阶段， 临床主要表现为呼吸困难、体液潴留以及乏力等[1-4]， 临床死亡率较高[2]。近年来， 临床中慢性充血性心力衰竭患者数量不断上涨， 对患者的生命安全有较大威胁。本文将本院收治的102例慢性充血性心力衰竭患者作为研究对象， 观察琥珀酸美托洛尔缓释片治疗慢性充血性心力衰竭的临床效果。现报告如下。
1 资料与方法
1. 1 一般资料 将本院2014年9月～2015年12月收治的102例慢性充血性心力衰竭患者纳入本次研讨范围， 采用双色球分组法分为对照组和观察组， 各51例。所有患者均符合慢性充血性心力衰竭相关诊断标准[3]；且对本次研究知情， 并签署知情同意书。排除琥珀酸美托洛尔缓释片以及其他相关药物禁忌者。对照组中， 男33例， 女18例；年龄63～82岁， 平均年龄(70.5±6.4)岁；心功能按纽约心脏病协会(NYHA)分级[5]， Ⅱ级14例， Ⅲ级27例， Ⅳ级10例。观察组中， 男32例， 女19例；年龄61～82岁， 平均年龄(69.7±6.3)岁；心功能按NYHA分级， Ⅱ级16例， Ⅲ级26例， Ⅳ级9例。两组患者一般资料比较， 差异无统计学意义(P>0.05)， 具有可比性。, http://www.100md.com(孙畅 张春敏 罗武奎)