雷贝拉唑联合左氧氟沙星与阿莫西林治疗消化性溃疡的疗效(1)
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【摘要】 目的 评价雷贝拉唑联合左氧氟沙星与阿莫西林治疗消化性溃疡(PU)的疗效。方法 将120例幽门螺杆菌(Hp)阳性的PU患者随机分为对照组及观察组，每组各60例。观察组给予雷贝拉唑10 mg、左氧氟沙星200 mg、阿莫西林1000 mg，均为2次/d口服。对照组给予奥美拉唑20 mg、克拉霉素500 mg、阿莫西林1000 mg，均为2次/d口服。疗程均为2周。停药后4周复查胃镜及Hp检测。结果 观察组总有效率95%，对照组总有效率80%；观察组Hp根除率为90%，对照组为70%。结论 雷贝拉唑联合左氧氟沙星与阿莫西林治疗Hp阳性的PU疗效好，是理想方法之一。
【关键词】
雷贝拉唑；左氧氟沙星；阿莫西林；克拉霉素；消化性溃疡；幽门螺杆菌
The therapeutic effect of triple combined regimen of Rabeprazole and Levofloxacin, Amoxicill therapy for peptic ulcer
WANG Zhaoxuan. Department of Digestive,The First Poeople’s Hospital of Jining,Shandong 272111,China
【Abstract】 Objective
To evaluate the therapeutic effect of triple therapy of Rabeprazole and Levofloxacin，Amoxicill combined for peptic ulcer.Methods 120 patients with helicobacter pylori(Hp)infection suffered from peptic ulcer were randomly divided into observation groupand control group,60 cases in each group.Observation group were administrated Rabeprazole(10 mg，twice a day)，Levofloxacin(200 mg，twice a day)and Amoxicill (1000 mg，twice a day)for two weeks.Control group were treated with Omeprazole(20 mg，twice a day)，Amoxicillin(500 mg，twice a day)and Clarithromycin(200 mg，twice a day)for two weeks.Four weeks later, the Hp eradication rate and the total effective rate were observed. Results After the treatment the total effective rate of the observation group was 95%, while that of the control group was 80%,the dfferences were statistically significant (P<0.05). The Hp eradication rate of the observation group was 90.0%,while that of the control group was 70%，there was significant difference between two groups(P<0.05).Conclusion Triple therapy of Rabeprazole and Levofloxacin，Omidazole combined is an effective method at the same time is one of the ideal methods for Hp infection suffered from peptic ulcer.
【Key words】
Rabeprazole； Levofloxacin； Amoxicill； Clarithromycin； Peptic ulcer； Helicobacter pylori
作者单位：272111山东省济宁市第一人民医院消化内科
消化性溃疡(peptic ulcer，PU)主要是指发生在胃和十二指肠的慢性溃疡，因溃疡的形成主要与胃酸、胃蛋白酶的消化作用有关，其病情绵延复杂，又与精神、情绪、心理有关，易于复发。研究发现幽门螺旋杆菌(Hp)抗生素耐药性的上升使发病率上升。综上PU的发生机制 ......
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